Experience and Education

• Ph.D., Physiology, Medical College of Georgia
• M.S., Exercise and Sports Science, University of Memphis
• B.S., Physical Education, Appalachian State University

Research 

My lab studies novel mechanisms that contribute to vascular deterioration in cardiovascular and metabolic diseases, as well as aging. Current hypotheses include dysregulation in cellular recycling (autophagy) and energy sensing. Furthermore, we are interested in understanding the mechanisms by which therapeutic interventions such as exercise and caloric restriction reverse vascular dysfunction.

Selected Publications

1. Wenceslau CF, McCarthy CG, Earley S, England SK, Filosa JA, Goulopoulou S, Gutterman DD, Isakson BE, Kanagy NL, Martinez-Lemus LA, Sonkusare SK, Thakore P, Trask AJ, Watts SW, & Webb RC. Guidelines for the measurement of vascular function and structure in isolated arteries and veins. Am J Physiol Heart Circ Physiol. 321(1): H77-H111, 2021.
2. McCarthy CG, Saha P, Golonka R, Wenceslau CF, Joe B, & Vijay-Kumar M. Innate immune cells and hypertension: Neutrophils and neutrophil extracellular traps (NETs). Compr Physiol. 11(1): 1575-1589, 2021.
3. Schreckenberger ZJ, Wenceslau CF, Joe B, & McCarthy CG. Mitophagy in hypertension-associated premature vascular aging. Am J Hypertens. 33(9): 804-812, 2020.
4. McCarthy CG, Wenceslau CF, Calmasini FB, Klee NS, Brands MW, Bina Joe, & Webb RC. Reconstitution of autophagy ameliorates vascular function and arterial stiffening in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 317(5): H1013-H1027, 2019.

Honors and Awards

1. American Physiological Society (APS) Cardiovascular Section Clinical Science Young Investigator Award Sponsored by Portland Press
2. Fellow of the AHA (FAHA) Council on Hypertension
3. NIH Pathway to Independence Award (K99/R00)
4. American Heart Association Career Development Award (CDA).